目的：通过随机对照试验，观察氦氖激光在喀什地区弱视儿童中的治疗效果。方法：选取2016年2月至2018年11月期间就诊喀什地区第一人民医院符合纳排标准的弱视儿童，按随机数字表法，分为试验组(氦氖激光+弱视常规治疗组)与对照组(弱视常规治疗组)，比较两组的弱视治疗效果。结果：本试验成功纳入弱视儿童111例(177眼)，其中试验组61例(97眼)，对照组50例(80眼)。与对照组相比，汉族试验组弱视儿童效果明显(P=0.023)，维吾尔族试验组弱视儿童未见明显疗效(P=0.481)；试验组与对照组在喀什地区不同年龄、不同弱视程度、不同弱视类型及不同弱视眼数儿童中未见明显差异(P>0.05)。结论：氦氖激光治疗喀什地区弱视儿童作用有限，为避免过度医疗，不建议在南疆地区开展。
Objective: To observe the therapeutic effect of helium-neon laser in amblyopia children in Kashgar by a randomized controlled trial. Methods: Amblyopia children who met eligibility criteria during February 2016 to November 2018 were selected and divided into two groups according to random number table: test group(helium-neon laser + conventional treatment for amblyopia) and control group (conventional treatment for amblyopia). The effects of amblyopia treatment were compared between two groups. Results: One hundred and eleven amblyopic children (177 eyes), including 61 children (97 eyes) of the test group and 50 children (80 eyes) of the control group were included in this study. The effect of helium-neon laser was significant in Han children (P=0.023), but not in Uygur children (P=0.481) in the test group compared with the control group.Conclusion: Helium-neon laser has limited effect in treating children with amblyopia in Kashgar region. To avoid over-treatment, it is not recommended to perform it in southern Xinjiang.
本文对7例正常人眼前房角小梁网进行了组织化学——酸性粘多糖及超微结构的研究。结果表明人类正常眼前房角小梁中存在酸性粘多糖,以内皮网处较多,大部分可被透明质酸酶消化。小梁带中螺旋纤维可能是小梁网柔韧性的结构基础,小梁带基板层与小梁带内皮细胞胞浆存在密切联系,小梁内皮细胞间的连接,可能对防止小梁带受外界因素影响而发生位移有一定稳固作用,内皮网间质中存在Ⅰ、Ⅱ型斑状物及胶原成分,39岁以下眼中含量较少,老年眼中较多。Schlemm 氏管内壁内皮细胞胞浆中液泡是房水排出的细胞内途径,证实了本文作者1963年提出的论点。
Histochemical and ultrastructural studies of the trabecular meshwork (TM) of 7 normal human eyes were carried out. The age of this group ranged between 20-70 years. Histochemical results showed that acid mucopolysaccharides existed in the TM of normal eyes, especially in the endothelial meshwork portion. Most of the acid mucopoly-saccharides were digestible by testicular hyaluronidase. The ultrastructural study indicated the following: 1. The spiral fibrils surrounding the collagen core of TM were spaced unequally in spiral distance and might wind loosely or tightly. This structure might be the anatomic basis of the flexibility of the trabeculae, 2. The discontinuous cytoplasmic membrane of the endothelium and the extention of the basal lamina to the endothelial cytoplasm as a process-like structure might imply that there were substances exchanged between the endothelial cells and the basal lamina of the trabeculae. 3. The structures known as tongue-in-groove and interdigitation joints were desmosomes or gap junctions between the adjacent cell membrane. These two junctional structures might act as stabilizers to prevent trabecular bands from moving when effected by outer environment. 4. The vacuoles within the cytoplasm of the endothelial cell lining the inner wall of Schlemm's canal might indicate that the aqueous outflow passes through intracellular path-way. This evidence confirmed our suggestion in 1963 which is consistent with many authors' idea.
