目的：比较不同预设光学区组的飞秒激光小切口基质透镜取出术(small incision lenticule extraction，SMILE)和飞秒激光制瓣联合准分子激光原位角膜磨镶术(femtosecond laser-assisted in situ keratomileuses，FS-LASIK)术后有效光学区(effective optical zone，EOZ)大小与角膜高阶像差(high order aberrations，HOAs)变化以及有效光学区大小对角膜高阶像差的影响。方法：收集2019年2月 至2020年5月来佛山市第二人民医院行激光手术的患者80例，均取右眼入组，SMILE组43例，FSLASIK组37例，按预设光学区大小分为6.5 mm和6.0 mm组，分别于术前和术后1个月应用Pentacam三维眼前节分析系统测量有效光学区及总角膜高阶像差、彗差、球差，分析不同预设光学区下SMILE组和FS-LASIK组有效光学大小及与角膜高阶像差的关系。结果：在相同预设光学区下，术后1个月SMILE组的有效光学区均大于FS-LASIK组，差异均有统计学意义(均P<0.05)，且SMILE组的角膜总高阶像差、球差、彗差均较FS-LASIK组低，差异均有统计学意义(均P<0.05)；对于相同手术方式，预设光学区6.0 mm较6.5 mm组，术后1个月角膜总高阶像差、球差、彗差均升高，差异均有统计学意义(均P<0.05)。结论：SMILE组和FS-LASIK组术后1个月的有效光学区均小于预设光学区，SMILE组大于FS-LASIK组；术后1个月有效光学区越大，角膜高阶像差越小；在相同预设光学区下，SMILE组术后1个月角膜高阶像差小于FS-LASIK组。

Objective: To compare the effective optical zone (EOZ) and the changes in corneal high order aberrations (HOAs) after small incision lenticule extraction (SMILE) with those after femtosecond laser-assisted in situ keratomileuses (FS-LASIK). Methods: This study included 80 subjects who underwent laser refractive surgery at the Second People’s Hospital of Foshan between February 2019 and May 2020. Only data from the right eye of each subject were analyzed. A total of 43 eyes underwent SMILE while 37 eyes received FS-LASIK. The eyes were further stratified into subgroups based on different programmed optical zones: the 6.5 mm group and the 6.0 mm group. EOZ, coma, and spherical aberration were measured with Pentacam 3D anterior segment analysis system preoperatively and one month postoperatively. In addition, the relationship between EOZ and corneal HOAs was analyzed and compared between different optical-zone groups after SMILE and FS-LASIK. Results: For the same programmed optical zone, the SMILE group achieved a significantly greater EOZ than the FS-LASIK group who was measured 1-month postoperatively did (P<0.05). Meanwhile, corneal HOAs, spherical aberration, and coma in the SMILE group are significantly lower than those in the FS-LASIK group (P<0.05). For the same procedure (SMILE or FS-LASIK), the 6.0 mm group demonstrated significantly higher corneal total HOAs, spherical aberration, and coma than the 6.5 mm group did 1-month after the surgery (P<0.05). Conclusion: In both the SMILE and the FS-LASIK groups, 1-month postoperative EOZ was smaller than the programmed optical zone. EOZ in the SMILE group was larger than that in the FS-LASIK group. The larger the 1-month postoperative EOZ was, the lower corneal HOAs were. For the same programmed optical zone, 1-month postoperative corneal HOAs in the SMILE group is lower than that in the FS-LASIK group.

目的：比较角膜生物力学分析仪(Corvis ST)、A型超声测厚仪(A超)、Lenstar LS 900(Lenstar)在测量近视眼角膜厚度的差异，为屈光术前筛查提供参考。方法：纳入2020年3至12月佛山市第二人民医院收治的屈光术前近视患者244例(244只右眼)，并按中央角膜厚度(central corneal thickness，CCT)将患者分为3组：薄角膜组(CCT≤520 μm)、正常角膜组(520 μm570 μm)，分别采用Corvis ST、A超、Lenstar三种仪器测量3组患者的中央角膜厚度，并纳入对比指标。结果：Corvis ST与A超、Lenstar在薄角膜组、正常角膜组、厚角膜组的测量值对比差异均有统计学意义(均P<0.05)；在相关性方面，Corvis ST与A超、Lenstar在薄角膜组、正常角膜组、厚角膜组呈正相关(r=0.841，P<0.001 vs r=0.832，P<0.001；r=0.866，P<0.001 vs r=0.918，P<0.001；r=0.497，P<0.001 vs r=0.801，P<0.001)；在一致性方面，Corvis ST与A超、Lenstar在薄角膜组、正常角膜组、厚角膜组上一致性系数ICC及95%置信区间分别为0.602(0.091，0.857)，0.758(0.221，0.901)、0.741(0.207，0.890)，0.845(0.396，0.938)、0.417(0.005，0.679)，0.667(0.172，0.851)，95%一致性区间范围分别是(-2.2~24.2 μm，-6.7~19.5 μm；-8.4~24.6 μm，-6.8~19.4 μm；-8.7~23.8 μm，-7.0~18.3 μm)。结论：通过对3组数据统计分析得出，Corvis ST与A超、Lenstar的测量值相比，差异均有统计学意义，且Corvis ST的测量值均高于后两种仪器；Corvis ST与后两者均有着较高的相关性，且在正常角膜厚度测量上相关性最高；在一致性方面，从ICC点估计及95%置信区间数值分析，一致性较差；从Bland-Altman角度分析，Corvis ST与后两者的绝对值最大差值超过10 μm，一致性较差，但在与Lenstar的绝对值最大差值均在20 μm内。因此，在测量精度要求较高的屈光手术筛查方面，Corvis ST与A超、Lenstar之间不能相互替代，而对于大规模临床筛查，其角膜厚度测量值对眼压的影响有一定的临床参考意义。

Objective: To compare the differences of corneal thickness measured by corneal biomechanical analyzer (Corvis ST), A-mode ultrasonic thickness meter (A-ultrasound) and Lenstar LS 900 (Lenstar) in myopia, so as to provide reference for preoperative screening of refractive surgery. Methods: A total of 244 patients (244 right eyes) with myopia before refractive surgery in Foshan Second People’s Hospital from March to December 2020 were included in the study, and the patients were divided into three groups according to the central corneal thickness (CCT): the thin cornea group (CCT≤520 μm), the normal cornea group (520 μm570 μm). The central corneal thickness (CCT) of the three groups was measured by Corvis ST, A-type ultrasonic thickness gauge and Lenstar LS 900, respectively, and included in the comparison index. Results: The measured values of Corvis ST, A-ultrasound and Lenstar in the thin cornea group, the normal cornea group and the thick cornea group were statistically significant (all P<0.05). Corvis ST was positively correlated with A-ultrasound and Lenstar in the thin cornea group, the normal cornea group and the thick cornea group (r=0.841, P<0.001 vs r=0.832, P<0.001; r=0.866, P<0.001 vs r=0.918, P<0.001; r=0.497, P<0.001 vs r=0.801, P<0.001). In terms of consistency, the consistency coefficients ICC of Corvis ST, A-ultrasound and Lenstar in the thin cornea group, the normal cornea group and the thick cornea group were 0.602 (0.091, 0.857), 0.758 (0.221, 0.901); 0.741 (0.207, 0.890), 0.845 (0.396, 0.938); 0.417 (0.005, 0.679), 0.667 (0.172, 0.851), and the range of 95% consistency interval were -2.2–24.2 μm, -6.7–19.5 μm; -8.4–24.6 μm, -6.8–19.4 μm; -8.7–23.8 μm, -7.0–18.3 μm. Conclusion: Through the statistical analysis of the data from the three groups, it is concluded that the measured values of Corvis ST are statistically significant compared with those of A-ultrasound and Lenstar, and the measured values of Corvis ST are higher than those of the latter two instruments. Corvis ST has a high correlation with the latter two, and the correlation is the highest in the measurement of normal corneal thickness. In terms of consistency, from the ICC point estimation and 95% confidence interval numerical analysis, the consistency was poor. From the perspective of Bland Altman, the maximum absolute value difference between Corvis ST and Lenstar was more than 10 μm, indicating poor consistency, but the maximum absolute value difference between Corvis ST and Lenstar was within 20 μm. Therefore, in refractive surgery screening with high measurement accuracy, Corvis ST, A-ultrasound and Lenstar cannot replace each other. However, in large-scale clinical screening, the measured value of corneal thickness has a certain clinical reference significance on the impact of intraocular pressure.

目的：基于新一代Corvis^® ST分析成人近视患者经飞秒激光小切口角膜透镜取出术(small incision corneal lens extraction，SMILE)后角膜体(corneal volumn，CV)的变化与角膜生物力学变化的相关性，进一步证明C V对于评估SMILE术后角膜生物力学特性以及预测屈光手术结果的价值。方法：采用前瞻性病例观察研究方法，纳入2021年1月至8月在佛山市第二人民医院拟行SMILE的成人近视患者72例(72眼)。为避免双眼相关性，纳入患者的一个合适眼(右眼或者左眼)，根据术前中央角膜厚度，将厚度470~<530 μm分为低角膜厚度组，530~<560 μm为中角膜厚度组 ， ≥560μm为高角膜厚度组。应用新一代 Corvis^® ST 于术前和术后3个月测量非接触生物力学校正眼压(biomechanical intraocular pressure，bIOP)、2 mm处变形幅度的比值[DA ratiomax(2 mm)，DA2ratio]、综合半径(integrated inverse concave radius，IR)、水平方向Ambr?sio相关厚度，最薄点厚度/厚度变化率(Ambrósio’s relational thickness，ARTh)、第1次压平时角膜硬度参数(stiffness parameter applanation 1，SP-A1)、Corvis生物力学指数(Corvis biomechanical index，CBI)和应力和应变参数(stress-strain index，SSI)7项角膜生物力学参数。应用Pentacam眼前节分析系统测量中央角膜厚度(central corneal thickness，CCT)和不同区域的CV(CV_3mm、CV_5mm、CV_7mm和CV_10mm)。对比SMILE术前与术后3个月的CV、角膜生物力学参数的变化，并分析角膜生物力学参数与CV的相关性。数据采用配对、独立样本t检验分析差异性；单因素方差分析不同角膜厚度组的差异性；Spearman相关性分析和偏最小二乘回归(partial least squares linear regression，PLSLR)分析相关性。结果：SMILE术后3个月，CV_3mm、CV_5mm、CV_7mm和CV_10mm均较术前显著下降(均P<0.001)；bIOP、ARTh、SP-A1和SSI较术前明显下降(P<0.05)；DA2ratio、IR和CBI较术前明显升高(P<0.05)。术前和术后3个月不同角膜厚度组的ARTh、SP-A1DA2ratio、IR和CBI差异均有统计学意义(均P<0.05)，低中角膜厚度组SSI术前后变化不大(P>0.05)。术前DA2ratio与CV_3mm、CV_5mm呈负相关，与CV_10mm呈正相关；ARTh与CV_3mm、CV_5mm呈正相关，与CV_10mm呈负相关；bIOP与CV_10mm呈正相关；IR与CV_3mm、CV_5mm呈负相关，与CV_10mm呈正相关；SP-A1与CV_3mm、CV_5mm呈正相关，与CV_10mm呈负相关；CBI与CV_3mm、CV_5mm和CV_10mm呈负相关，SSI与CV_3mm呈正相关，与CV_10mm呈负相关。SMILE术后3个月，ARTh与CV_3mm、CV_5mm呈正相关，与CV_10mm呈负相关；CBI与CV_3mm负相关、CV_10mm呈正相关(均P<0.05)。SMILE术后3个月变化量中，ARTh与CV_3mm、CV_5mm呈正相关，与CV_10mm负相关；CBI与CV_3mm呈负相关，与CV_10mm呈正相关(均P<0.05)。结论：成人SMILE术后3个月CV_3mm、CV_5mm、CV_7mm、CV_10mm、眼压和CCT较术前均显著降低；越往周边区域CV减少量越多。SMILE术后3个月的新一代Corvis^® ST角膜生物力学新型参数较术前有显著变化；不同区域CV与角膜生物力学参数存在一定的相关性，预期SMILE术后不同区域的CV可以表征术后部分角膜生物力学特性的改变，CV可能成为表征预测角膜扩张发展的参数因素。

Objective: To evaluate the changes in corneal volume (CV) and the correlation of corneal biomechanics in adult myopic patients after small incision corneal lens extraction (SMILE) based on the new generation of Corvis^® ST.This paper further demonstrates the value of CV in evaluating corneal biomechanical properties after SMILE and predicting the outcome of refractive surgery. Methods: A total of 72 cases (72 eyes) of adult myopia who were scheduled for SMILE in The Second People’s Hospital of Foshan from January to August 2021 were included in this prospective observational case study. To avoid binocular correlation, a suitable eye for each person was selected for inclusion. Based on the preoperative central corneal thickness (CCT), the cases were divided into a low corneal thickness group (470–<530 μm), a medium corneal thickness group (530–<560 μm), and a high corneal thickness group (≥560 μm). The biomechanical intraocular pressure (bIOP), DA ratiomax (2 mm) (DA2ratio), integrated inverse concave radius (IR), Ambrósio’s relational thickness (ARTh), stiffness parameter applanation 1 (SP-A1),corvis biomechanical index (CBI) and stress-strain index (SSI) were measured by Corvis^® ST. The Pentacam anterior segment analysis system was used to measure partial CV and total CV with a diameter of 3, 5, and 7 mm from the top of the cornea, with an assumed diameter of 10 mm. The changes in corneal biomechanical parameters and CV before SMILE and 3 months after SMILE were compared. The correlation between corneal biomechanical parameters and CV was studied. Data were analyzed by paired and independent sample t-tests. One-way analysis of variance (ANOVA) was used to assess the differences between the corneal thickness groups. Spearman correlation analysis and partial least squares linear regression (PLSLR) were used for correlation analyses. Results: Three months after SMILE, the CV in different areas (CV_3mm, CV_5mm, CV_7mm, and CV_10mm) were significantly lower than those before SMILE, and the differences were statistically significant (all P<0.001). The corneal biomechanical parameters bIOP, ARTh, SP-A1, and SSI were significantly decreased compared with those before the operation (P<0.05). In contrast, the DA2 ratio, IR, and CBI were significantly higher than those before the operation (P<0.05). A comparison of the corneal biomechanical parameters ARTh, SP-A1, DA2 ratio, IR, and CBI in the different corneal thickness groups before and after SMILE showed overall differences among the groups (P<0.05).However, there was no significant change in the SSI between the low and medium corneal thickness groups. The correlation of the preoperative baseline DA2ratio was negatively correlated with CV_3mm and CV_5mm, and positively correlated with CV_10mm; Conversely, ARTh was positively correlated with CV_3mm and CV_5mm, and negatively correlated with CV_10mm; BIOP was positively correlated with CV_10mm; IR was negatively correlated with CV_3mm and CV_5mm, and positively correlated with CV_10mm; SP-A1 was positively correlated with CV_3mm and CV_5mm, and negatively correlated with CV_10mm; CBI was negatively correlated with CV_3mm, CV_5mm, and CV_10mm, while SSI was positively correlated with CV_3mm and negatively correlated with CV_10mm (all P<0.05). At 3 months after SMILE, ARTh was positively correlated with CV_3mm and CV_5mm, and negatively correlated with CV_10mm; CBI was negatively correlated with CV_3mm, and positively correlated with CV_10mm (all P<0.05). Conclusion: This study demonstrated that at 3 months after SMILE, CV_3mm, CV_5mm, CV_7mm, CV_10mm, intraocular pressure, and CCT in the central and peripheral areas decreased significantly compared with to those before the operation, and the more peripheral the area, the more the CV decreased. Three months after SMILE, the new corneal biomechanical parameters of the new generation Corvis^® ST changed significantly compared to those before the operation, and there was a certain correlation between CV in different regions and corneal biomechanical parameters. It is expected that CV in different regions after SMILE can characterize some changes in corneal biomechanical properties after SMILE, and CV may become a parameter factor for characterizing and predicting the development of corneal dilatation.