图1 泪阜部色素痣合并鳞状细胞乳头状瘤的外眼观及病理组织学特征

Figure 1 Clinical appearance and pathological features of pigment nevus of lacrimal caruncle complicated with squamous cell papilloma

(A)右眼泪阜部可见红色肿物，表面粗糙，表面及基底部可见色素沉着。(B)结膜色素痣为复合痣，表面结膜上皮呈乳头状增生(黑色箭头所示)，结膜下基质内可见巢状分布的痣细胞，含较多黑色素性颗粒(黄色箭头所示；HE，×100)。(C)乳头状增生的上皮细胞分化较好，上皮内可见结膜杯状细胞(HE，×400)。(D)右眼泪阜部棕黑色肿物，边界清晰，其一侧边缘可见粉白色乳头状肿物。(E)结膜色素痣为皮内痣(黄色箭头所示)，表面的结膜上皮呈乳头状增生，乳头内可见纤维血管束(黑色箭头所示；HE，×100)。(F)痣细胞巢之间可见微小的结膜上皮囊肿(HE，×200)。(G)Ki-67主要表达于鳞状细胞乳头状瘤基底部胞核内，阳性指数较低(IHC，×200)。(H)鳞状细胞乳头状瘤的上皮和基质中结膜上皮囊肿的囊壁上皮对CK呈阳性表达，色素痣细胞呈阴性表达(IHC，×200)。

(A) There was a red mass in the lacrimal caruncle, with rough surface and pigmentation on the surface and base. (B) The conjunctival epithelium on the surface of the compound nevus showed papillary hyperplasia (Black arrow). Nestlike nevus cells were found in the subconjunctival matrix, which contained many dark pigmented particles (yellow arrow; HE, ×100). (C) The papillary hyperplasia was well difffferentiated, and the squamous cell papilloma absence of goblet cells (HE, ×400). (D) There was a brown mass in the right lacrimal caruncle, with a clear boundary and a papillary mass of the conjunctiva. (E) The surface of the intradermal nevus (yellow arrow) showed papillary hyperplasia (black arrow). Fibrovascular bundles can be seen in the papilloma (HE, ×100). (F) Conjunctival epithelial cysts can be seen in the stroma of the pigmented nevus (HE, ×200). (G) Ki-67 was mainly expressed in the nucleus of the basement cells of papilloma, and the expression index of Ki-67 was low (IHC, ×200). (H) CK was mainly expressed in papilloma and conjunctival epithelial cysts, and no positive expression was found in nevus cells (IHC, ×200).