目的：观察强脉冲光(intense pulse light，IPL)治疗睑板腺功能障碍(meibomian gland dysfunction，MGD)性干眼的临床效果。方法：选取2019年10月至2019年12月在东莞市东南部中心医院眼科门诊就诊的MGD性干眼患者64例(64只右眼)，随机分为对照组与观察组，每组32例。对照组采用睑板腺按摩联合常规药物治疗，观察组采用IPL联合睑板腺按摩及常规药物治疗，两组疗程均为6周；观察两组患者治疗前后干眼症状、体征及睑板腺功能变化。结果：治疗后两组干眼症状、体征及睑板腺功能均较治疗前明显改善，差异有统计学意义(P>0.05)；观察组治疗后2、4周干眼症状、体征及睑板腺功能评分改善优于对照组，差异有统计学意义(P<0.05)；治疗后6周两组各项观察指标差异无统计学意义(P>0.05)。经过6周治疗，观察组有效率为87.5%(28/32)，对照组有效率75%(24/32)，差异有统计学意义(P=0.021)。治疗期间两组均未发生不良反应。结论：IPL联合睑板腺按摩对MGD性干眼能有效减轻眼部不适症状、改善睑板腺功能，较单纯睑板腺按摩起效更快、效果更佳。

Objective: To observe the clinical effect of intense pulse light (IPL) on MGD dry eyes. Methods: Sixty-four patients(64 right eyes) with MGD dry eye from October 2019 to December 2019 were collected and randomly divided into control group (n=32) and observation group (n=32). The control group was treated with meibomian gland massage combined with conventional medicine, while the observation group was treated with IPL combined with meibomian gland massage and conventional medicine. The course of treatment of both groups was 6 weeks. The dry eye symptoms, dry eye signs and meibomian gland function changes were observed before and after treatment in both groups. Results: The dry eye symptoms, physical signs and meibomian gland function of the two groups after treatment were significantly improved compared with those before treatment (P>0.05). The improvement of dry eye  symptoms, physical signs and meibomian gland function in observation group were better than those of the control group at two and four weeks after treatment (P<0.05), while there was no statistically significant difference between the two groups at 6 weeks after treatment (P>0.05). The effective rate in observation group was 87.5% (28/32) after 6 weeks treatment, while control group was 75% (24/32), the difference was statistically significant (P=0.021). No adverse reactions occurred in both groups during the treatment. Conclusion: IPL combined with meibomian gland massage can effectively reduce the ocular discomfort and improve the function of meibomian gland in MGD dry eyes,which is faster and more effective than meibomian gland massage alone.

目的：观察强脉冲光(intense pulse light，IPL)治疗睑板腺功能障碍(meibomian gland dysfunction，MGD)性干眼的临床效果。方法：选取2019年10月至2019年12月在东莞市东南部中心医院眼科门诊就诊的MGD性干眼患者64例(64只右眼)，随机分为对照组与观察组，每组32例。对照组采用睑板腺按摩联合常规药物治疗，观察组采用IPL联合睑板腺按摩及常规药物治疗，两组疗程均为6周；观察两组患者治疗前后干眼症状、体征及睑板腺功能变化。结果：治疗后两组干眼症状、体征及睑板腺功能均较治疗前明显改善，差异有统计学意义(P<0.05)；观察组治疗后2、4周干眼症状、体征及睑板腺功能评分改善优于对照组，差异有统计学意义(P<0.05)；治疗后6周两组各项观察指标差异无统计学意义(P>0.05)。经过6周治疗，观察组有效率为87.5%(28/32)，对照组有效率75%(24/32)，差异有统计学意义(P=0.021)。治疗期间两组均未发生不良反应。结论：IPL联合睑板腺按摩对MGD性干眼能有效减轻眼部不适症状、改善睑板腺功能，较单纯睑板腺按摩起效更快、效果更佳。

Objective: To observe the clinical effect of intense pulse light (IPL) on MGD dry eye. Methods: A totaly of 64 patients (64 right eyes) with MGD dry eye from October 2019 to December 2019 in ophthalmology clinic of Dongguan Southeast Central Hospital were collected and randomly divided into control group (n=32) and observation group (n=32). The control group was treated with meibomian gland massage combined with conventional medicine, while the observation group was treated with IPL combined with meibomian gland massage and conventional medicine. The treatment course of both groups was 6 weeks. The changes of dry eye symptoms, physical signs and meibomian gland function were observed before and after treatment in both groups. Results: The dry eye symptoms, physical signs and meibomian gland function of the two groups after treatment were significantly improved compared with those before treatment (P<0.05), the difference was statistically significant. The improvement of dry eye symptoms, physical signs and meibomian gland function in observation group were better than those in the control group two and four weeks after treatment (P<0.05), and the difference was statistically significant, while there was no statistically significant difference between the two groups 6 weeks after treatment (P>0.05). The effective rate in observation group was 87.5% (28/32) after 6 weeks of treatment, while that in control group was 75% (24/32), and the difference was statistically significant (P=0.021). No adverse reactions occurred in both groups during the treatment. Conclusion: IPL combined with meibomian gland massage can effectively reduce the ocular discomfort and improve the function of meibomian gland in MGD dry eye, which is faster and more effective than meibomian gland massage alone.