目的：评价丙泊酚-阿芬太尼-利多卡因混合剂在成人白内障日间手术中的麻醉镇静效果与不良反应。方法：回顾性分析2021年1月至2021年6月中山大学中山眼科中心接受丙泊酚-阿芬太尼-利多卡因静脉镇静下白内障日间手术的患者(静脉镇静组，n=30)，并匹配同一主刀医师、诊断相似且在丙美卡因表面麻醉下白内障手术患者(表麻组，n=30)。比较两组患者围手术期血流动力学变化、手术中眼位评级、手术中断的次数、手术时间、手术后苏醒时间、出院时间、术中手术体验以及术后不良事件等指标。结果：所有患者均在原麻醉方式下顺利完成手术；与表麻组相比，静脉镇静组手术中断次数显著降低(P<0.05)，围手术期血压更平稳，且术后满意度评价明显升高(P<0.05)。结论：丙泊酚-阿芬太尼-利多卡因静脉镇静能显著提升白内障日间手术患者的就医体验，而不影响手术进程。

Objective: The aim of this study is to observe the efficacy and safety of propofol-alfentanil-lidocaine mixture in adult patients for cataract ambulatory surgery. Methods: Thirty adult patients undergoing cataract ambulatory surgery sedated by propofol-alfentanil-lidocaine mixture from January 2021 to June 2021 were enrolled in this retrospective study (sedation group, n=30). Meanwhile, another thirty patients with similar diagnosis performed by the same surgeons under topical anesthesia were matched in this study (topical anesthesia group, n=30). The scores of intraoperative eye position, the number of surgical interruptions due to poor cooperation, surgical time, emergence time, time to discharge, changes in blood pressure, surgical experience, as well as any adverse events were compared between the two groups. Results: The surgeries were successfully completed in all patients in both groups. Compared to topical anesthesia group, patients under sedation showed less surgical interruptions and more stable hemodynamics during the surgery, as well as better surgical experience (all P<0.05). Conclusion: Sedation with propofol-alfentanil-lidocaine mixture can significantly improve the surgical experience of patients undergoing cataract ambulatory surgery without prolonging duration of the surgery.