目的：探讨大气污染物NO₂水平与干眼患病的相关性。方法：选取2014年1月至2018年1月共计75 279例干眼患者的临床资料，进行资料汇总。空气质量和天气数据来自西安市气象局2014—2018年的每日环境空气质量数据。分析中包括的环境空气污染物NO₂。所有数据均按小时收集。计算每个变量的每日平均值，并计算本研究中使用的每周平均值。本研究中患者均自愿参加，并经南昌大学第一附属医院医学研究伦理委员会批准。结果：干眼的门诊就诊次数与NO₂水平显著相关。本研究发现不同年龄段的人受到不同的参数变化影响，环境中NO₂的浓度对于全年龄段的人患干眼有显著相关性，对性别无选择性，男女均会因为NO2在环境中的不同水平而患干眼。较高水平的环境NO₂会增加门诊患者干眼的概率。我们通过对患者人数的累计与环境中NO₂浓度进行相关性分析，发现其有显著相关性，因此环境空气污染和天气变化可能导致干眼的恶化。结论：大气污染物NO2与干眼患病有显著相关性。

Objective: To investigate the correlation between NO₂ levels in air pollutants and dry eye. Methods: The clinical data of 75 279 patients with dry eye from January 2014 to January 2018 were selected and summarized. The air quality and weather data were from the daily ambient air quality data of Xi’an Meteorological Bureau from 2014 to 2018. Environmental air pollutants NO₂ was included in the analysis. All data were collected on an hourly basis. We calculated the daily average for each variable and then calculated the weekly average used in this study.All patients in this study volunteered to participate. , and this study was approved by the Medical Research Ethics Committee of the First Affiliated Hospital of Nanchang University. Results: We found that the number of outpatient visits for dry eye was significantly correlated with NO₂ levels. Our study found that people of different ages were affected by different parameter changes. The concentration of NO₂ in the environment was significantly correlated with dry eyes in all age groups, and is not selective for gender. Both men and women could develop dry eyes due to different levels of NO₂ in the environment. Our results showed that higher levels of environmental NO₂ increased the chances of dry eyes in outpatients. By analyzing the correlation between the cumulative number of patients and the NO₂ concentration in the environment, we found that the correlation was significant.Therefore, ambient air pollution and weather changes may lead to the deterioration of dry eye. Conclusion: There is a significant correlation between atmospheric pollutant NO₂ and dry eye disease.

目的：探讨大气污染物NO2水平与干眼患病的相关性。方法：选取2014年1月至2018年1月共计75 279例干眼患者的临床资料，进行资料汇总。空气质量和天气数据来自西安市气象局2014—2018年的每日环境空气质量数据。分析中包括的环境空气污染物NO2。所有数据均按小时收集。计算每个变量的每日平均值，并计算本研究中使用的每周平均值。本研究中患者均自愿参加，并经南昌大学第一附属医院医学研究伦理委员会批准。结果：干眼的门诊就诊次数与NO2水平显著相关。本研究发现不同年龄段的人受到不同的参数变化影响，环境中NO2的浓度对于全年龄段的人患干眼有显著相关性，对性别无选择性，男女均会因为NO2在环境中的不同水平而患干眼。较高水平的环境NO2会增加门诊患者干眼的概率。我们通过对患者人数的累计与环境中NO2浓度进行相关性分析，发现其有显著相关性，因此环境空气污染和天气变化可能导致干眼的恶化。结论：大气污染物NO2与干眼患病有显著相关性。

Objective: To investigate the correlation between NO2 levels in air pollutants and dry eye. Methods: The clinical data of 75 279 patients with dry eye from January 2014 to January 2018 were selected and summarized. The air quality and weather data were from the daily ambient air quality data of Xi’an Meteorological Bureau from 2014 to 2018. Environmental air pollutants NO2 was included in the analysis. All data were collected on an hourly basis. We calculated the daily average for each variable and then calculated the weekly average used in this study. All patients in this study volunteered to participate. , and this study was approved by the Medical Research Ethics Committee of the First Affiliated Hospital of Nanchang University. Results: We found that the number of outpatient visits for dry eye was significantly correlated with NO2 levels. Our study found that people of different ages were affected by different parameter changes. The concentration of NO2 in the environment was significantly correlated with dry eyes in all age groups, and is not selective for gender. Both men and women could develop dry eyes due to different levels of NO2 in the environment. Our results showed that higher levels of environmental NO2 increased the chances of dry eyes in outpatients. By analyzing the correlation between the cumulative number of patients and the NO? concentration in the environment, we found that the correlation was significant. Therefore, ambient air pollution and weather changes may lead to the deterioration of dry eye. Conclusion: There is a significant correlation between atmospheric pollutant NO2 and dry eye disease.