Fungal corneal ulcer is an infectious corneal disease with a high risk of blindness, and early diagnosis and treatment are particularly important for the prognosis of patients. Corneal scraping microscopy can assist in the diagnosis of fungal keratitis, while corneal scraping fungal culture is the gold standard for diagnosing fungal keratitis. This article reports a case of fungal keratitis caused by the rare fungus Sarocladium. Through the combination of corneal laser scanning confocal microscopy and corneal ulcer scraping fungal culture, the diagnosis of Sarocladium keratitis was confirmed by the rapid identification of mass spectrometer, and intimately fungal treatment was carried out, The patient's prognosis was good. Based on this, the diagnostic methods for Sarocladium keratitis are summarized in order to provide new ideas for the clinical diagnosis of rare fungal genera.
Myopia has become an important public health problem worldwide, and more and more studies have focused on the effects of light on myopia, with light intensity, light wavelength, light frequency and rhythm all influencing the refractive development of the eye. In this paper, we summarize the relationship between different light environments and myopia and their mechanisms of action, with a view to providing new ideas for the prevention and control of myopia.
Purpose: To investigate the effects of surgical intervention on visual function and quality of life in patients with orbital fractures. Methods: We retrospectively analyzed the clinical data of 180 patients with orbital fractures treated at our hospital from January 2021 to December 2022. Based on different treatment modalities, patients were divided into a conservative group (mainly corticosteroid conservative treatment) and a surgical group (surgical intervention). Propensity score matching was used to balance covariates between the two groups. After matching, each group had 36 patients. Visual acuity levels before and after treatment and Short Form-36 Health Survey (SF-36) scores were compared between the two matched groups. Adverse reactions and complications were also recorded. Results: After treatment, the surgical group had higher SF-36 scores than the conservative group in physical functioning (79.58±8.14 vs 75.32±7.46), social functioning (78.28±7.96 vs 73.31±6.80), role-physical (79.30±7.80 vs 74.12±7.96), mental health (78.82±7.62 vs 73.46±7.50), bodily pain (78.42±6.40 vs 73.10±6.25), role-emotional (79.85±6.85 vs 74.76±6.30), vitality (78.90±6.92 vs 73.32±6.50), and general health (79.14±6.85 vs 72.76±6.60). The differences between the two groups were statistically significant (t=2.315, 2.848, 2.789, 3.008, 3.568, 3.282, 3.526, 4.024; P=0.024, 0.006, 0.007, 0.004, 0.001, 0.002, 0.001, 0.001). The incidence of adverse reactions and complications was 5.56% in the surgical group and 8.33% in the conservative group, with no significant difference between the two groups (χ2=0.215, P=0.643). Conclusions: Surgical intervention can improve visual function and quality of life in patients with orbital fractures, and is worth adopting.
A patient with myelodysplastic syndrome showed numerous scattered red lesions on the face and trunk after 1 month of intravenous injection of camrelizumab. One popular with a diameter of about 3 mm was in a special position in the palpebral margin. Combined with medical history and clinical features,the patient was diagnosed as reactive cutaneous capillary endothelial proliferation(RCCEP) of the palpebral margin. At follow-up 6 months after the patient stopped calerizumab,the lesions subsided. Camrelizumab plays an important role in the treatment of myelodysplastic syndrome, and can cause adverse reactions such as RCCEP, which is self-limiting after withdrawal.
A patient with myelodysplastic syndrome showed numerous scattered red lesions on the face and trunk after 1 month of intravenous injection of camrelizumab. One popular with a diameter of about 3 mm was in a special position in the palpebral margin. Combined with medical history and clinical features,the patient was diagnosed as reactive cutaneous capillary endothelial proliferation(RCCEP) of the palpebral margin. At follow-up 6 months after the patient stopped calerizumab,the lesions subsided. Camrelizumab plays an important role in the treatment of myelodysplastic syndrome, and can cause adverse reactions such as RCCEP, which is self-limiting after withdrawal.
With the widespread application of functional intraocular lense (IOL), the accuracy of refractive prediction in cataract patients is increasingly important. Although IOL power calculation formulas have been innovated continuously in recent years, there are still challenges in predicting refractive powerin cataract patients with abnormal anatomical parameters, ocular comorbidities, or a history of ocular surgery. Based on the the characteristics of biological parameters and medical history to selcet appropriate IOL power formula, it is an important guarantee for accurate refractive prediction in cataract patients.
AIM： To explore the clinical treatment of peripheral necrotizing keratitis after femtosecond laser-assisted??in situ?keratomileusis (FS-LASIK). METHODS：Retrospective case-control study. A total of 18,448 cases of FS-LASIK were collected in our hospital from 2022-06/2023-05. 22 cases and 39 eyes of patients with peripheral necrotizing keratitis were observed. The scope of peripheral corneal necrosis were examined under a slit lamp microscope and treated accordingly. And 30 cases of patients who were operated on the same day were randomly selected as the control group. Observe the changes in naked eye visual acuity, diopters and intraocular pressure between the two groups after cure. RESULTS：Among the 18,448 cases, 22 patients and 39 eyes with peripheral necrotizing keratitis were found, with an incidence rate of 1.2‰, including 4 males and 18 females, aged 31 ± 5.0 years old. Topical tobramycin and dexamethasone eye drops were administered once an hour and in descending order every other day. The patient's pain, foreign body sensation, and tearing symptoms were significantly relieved. Most of the peripheral corneal necrosis lesions improved in 1 week, and gradually healed to form interlaminar clouds in 2 weeks. After treatment, the naked eye visual acuity, intraocular pressure, and diopters of the PNK group showed no significant changes compared with those of the control group. No glucocorticoid-induced intraocular hypertension occurred. CONCLUSION：Topical tobramycin and dexamethasone eye drops have a good therapeutic effect on peripheral necrotizing keratitis. The necrotic area forms scars after healing. The PNK case in this article is limited to the periphery and has no significant impact on naked eye vision, intraocular pressure, and diopters. KEYWORDS：Femtosecond laser-assisted??in situ?keratomileusis; Peripheral necrotizing keratitis; Diffuse lamellar keratitis; Postoperative complications; Glucocorticoids
Leukemia is a kind of myeloproliferative malignant clonal disease, its first symptoms are diverse, but with vision for first symptoms rare [1], with fever, fatigue, liver and spleen galomegaly for first symptoms, through this paper reported 1 case with vision for for chronic granular leukemia cases, for future clinical work experience, in order to improve the early diagnosis, avoid misdiagnosis, diagnosis.
Abstract: Objective To retrieve and analyze the clinical trials of Chinese medicine against dry eye disease(Dry eye disease，DED) included in the China Clinical Trial Registry (ChiCTR), and to understand their distribution characteristics and development trends. Methods A computerized search was performed on the clinical trials related to the prevention and treatment of dry eye in TCM included in ChiCTR from the establishment of the database to January 27, 2024, data were extracted and entered into Excel 365 for de-emphasis, and the included data were statistically analysed using the SPSS 26.0 software, and the corresponding charts were plotted to summarize the characteristics of the clinical trials. Results A total of 29 clinical trials were included, of which 24 were pre-registered. The registered research projects involved 8 provincial administrative regions and 21 clinical trial organizations in Shanghai, Beijing, Guangdong, Hunan, Zhejiang, Fujian, Shenzhen, and Hubei provinces, among which the Shanghai Institute of Acupuncture and Meridian Research (7 projects, 24.14%) registered the largest number of projects. The sources of funding were mainly 13 local finance (43.33%), self-funding (26.67%), university research funding (10.00%), pharmaceutical company funding (10.00%), hospital funding (6.67%), and national financial support (3.33%). The types of studies were mostly intervention studies (24, 87.76%), and the study design was most frequently randomized parallel controlled studies (25, 86.20%). Interventions included acupuncture, classic Chinese herbal formulas/hospital-made formulas, and proprietary Chinese medicines, and outcome indicators included primary, secondary, side effect, and additional indicators. Conclusion The rise in the number of clinically registered trials of Chinese medicine against dry eye in China tends to stabilize, the distribution of registration areas is not balanced, and the filling of clinical trial data is incomplete and not standardized, and the follow-up should strengthen the training of investigators about clinical trial registration and improve the awareness of clinical trial registration among investigators.
