Review Article

Novel treatments and genetics of age-related macular degeneration-a narrative review

2021,6(4):-
Amir Arabi,Toktam Shahraki

Abstract: Age-related macular degeneration (AMD) remains a leading cause of severe visual impairment in developing countries. Although dry-type AMD and geographic atrophy (GA) are progressive conditions with the associated decrease of visual functions, no well-established treatment regimen was proposed for the disease. Wet-type AMD is effectively treated with intravitreal anti-angiogenic agents, but frequent injections are a major issue for the affected patients. Recent advances in AMD genetics have provided new insights into the pathogenesis and novel therapeutic targets of AMD, but the benefits of using genetic testing and genotype-based risk models for AMD development and progression still lacks evidence. Novel AMD treatments aim to increase the interval among intravitreal injections through new therapeutic agents and modern delivery devices. Simultaneously, gene therapy for dry and wet AMD is widely studied. Although gene therapy possesses a major superiority over other novel treatments regarding a persistent cure of disease, many challenges exist in the way of its broad impact on the ocular health of AMD patients.

Current Issue
  • 眼科学报

    Executive director:Ministry of Education of the People's Republic of China
    Host: Sun Yat-sen University
    Undertake: Zhongshan Ophthalmic Center, Sun Yat-sen University
    Editors-in-Chief: 林浩添
    Executive director:Ministry of Education of the People's Republic of China
    Host: Sun Yat-sen University
    Browse
  • Eye Science

    Executive director:Ministry of Education of the People's Republic of China
    Host: Sun Yat-sen University
    Undertake: Zhongshan Ophthalmic Center, Sun Yat-sen University
    Editors-in-Chief: 林浩添
    Executive director:Ministry of Education of the People's Republic of China
    Host: Sun Yat-sen University
    Browse
Publishing Information
Copyright of Zhongshan Ophthalmic Center, Sun Yat-sen University粤ICP备:11021180